SERPINB2 Antikörper (Internal Region)

Produktnummer ABIN401463

Der Kaninchen Polyklonal anti-SERPINB2 Antikörper (ABIN401463) detektiert spezifisch SERPINB2 in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Primate.

Kurzübersicht für SERPINB2 Antikörper (Internal Region) (ABIN401463)

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Reaktivität: Human, Primate

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SERPINB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SERPINB2 Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody is directed against PAI-2 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Primates.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide corresponding to an internal area of human PAI-2 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/100,000 - 1/150,000. Western Blot: 1/500 - 1/2,000
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.2 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu SERPINB2

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Andere Bezeichnung: SERPINB2 / PAI2

Substanzklasse: Amino Acid

Hintergrund: Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60- kDa, secreted, extracellular, glycosylated form and a 43- kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.Synonyms: Monocyte Arg-serpin, PAI-2, PLANH2, Placental plasminogen activator inhibitor, Plasminogen activator inhibitor 2, Serpin B2, Urokinase inhibitor

Gen-ID: 5055

NCBI Accession: NP_001137290

UniProt: P05120

Pathways: Autophagie