MYB Antikörper (Internal Region)

Produktnummer ABIN401455

Der Kaninchen Polyklonal anti-MYB Antikörper wird verwendet zum Nachweis von MYB in Proben von Human, Maus, Ratte, Pferd, Schwein, Affe, Bonobo, Schimpanse, Gorilla, Opossum und Orang-Utan. Er wurde validiert für WB und EIA.

Kurzübersicht für MYB Antikörper (Internal Region) (ABIN401455)

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Reaktivität: Human, Maus, Ratte, Pferd, Schwein, Affe, Bonobo, Schimpanse, Gorilla, Opossum, Orang-Utan

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-MYB Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody reacts with endogenous c-Myb protein and also SUMOylated overexpressed c-Myb protein in transfected Cos7 cells.

Aufreinigung: Affinity chromatography

Immunogen: Peptide corresponding to an internal portion of the c-Myb protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10,000 - 1/25,000. Western Blot: 1/250 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu MYB

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Andere Bezeichnung: MYB

Hintergrund: The transcription factor c-Myb plays an important role in the development of all hematopoietic lineages during definitive hematopoiesis. Its critical role in hematopoiesis has been first demonstrated in experiments with targeted disruption of the c-Myb gene where deletion of both alleles of the c-Myb gene was embryonally lethal due to severe anemia. c-Myb is a short-lived sequence specific DNA-binding protein that regulates transcription of several important genes involved directly in cellular processes such as proliferation, differentiation, and apoptosis. Posttranslational modifications such as phosphorylation, acetylation, ubiquitination, and conjugation of SUMO proteins are crucial for modulation of the transactivation activity of c-Myb.Synonyms: Proto-oncogene c-Myb, Transcriptional activator Myb, c-Myb

Gen-ID: 17863

NCBI Accession: NP_001185843

UniProt: P06876

Pathways: Chromatin Binding, Positive Regulation of Immune Effector Process