IL7R Antikörper (pTyr449)

Produktnummer ABIN401417

Der Kaninchen Polyklonal anti-IL7R Antikörper wird verwendet zum Nachweis von IL7R in Proben von Human, Maus und Ratte. Er wurde validiert für WB und EIA.

Kurzübersicht für IL7R Antikörper (pTyr449) (ABIN401417)

Target: IL7R (Interleukin 7 Receptor (IL7R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL7R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-IL7R Antikörper

Bindungsspezifität: pTyr449

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide corresponding to residues near Y449 of mouse IL-7 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/100,000. Western Blot: 1/1,000 - 1/10,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.1 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Andere Bezeichnung: CD127 / IL7R

Hintergrund: Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R), the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.Synonyms: IL-7R-alpha, IL7 receptor alpha, Interleukin-7 receptor subunit alpha

Gen-ID: 10090

UniProt: P16872

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size