FKBP8 Antikörper (Internal Region)

Produktnummer ABIN401051

Der Kaninchen Polyklonal anti-FKBP8 Antikörper wird verwendet zum Nachweis von FKBP8 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und EIA.

Kurzübersicht für FKBP8 Antikörper (Internal Region) (ABIN401051)

Target: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FKBP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-FKBP8 Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody is specific for FKBP8 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: Synthetic peptide corresponding to an internal region of human FKBP8 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/25000. Western Blot: 1/500 - 1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 2.3 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu FKBP8

Target: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Andere Bezeichnung: FKBP8 / FKBP38

Hintergrund: FKBP8 (also known as FK506-binding protein 38) is a member of the immunophilin family that has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP8 by RNAi or transfection of a mutant FKBP8 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP8 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.Synonyms: 38 kDa FK506-binding protein, FK506-binding protein 8, Peptidyl-prolyl cis-trans isomerase FKBP8, Rotamase

Gen-ID: 23770

NCBI Accession: NP_036313

UniProt: Q14318

Pathways: Autophagie