JAG1 Antikörper (AA 110-125)

Produktnummer ABIN401024

Produktdetails anti-JAG1 Antikörper

Target: JAG1 (Jagged 1 (JAG1))

Bindungsspezifität: AA 110-125

Reaktivität: Human, Maus, Ratte, Schimpanse

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This protein A purified antibody is directed against Human Jagged-1 protein. Expect a band approximately 150 kDa in size corresponding to Jagged-1 in Mouse liver whole cell lysates, and a 75 kDa band in Human brain and kidney lysates. A BLAST analysis was used to suggest cross reactivity with Jagged-1 protein from Human, Chimpanzee, Rat and Mouse based on 100 % homology with the immunizing sequence. Partial reactivity is expected against dog (81 %) and Xenopus laevis (85 %) based on partial sequence homologies as indicated. Reactivity against homologues from other sources is not known.

Kreuzreaktivität (Details): Species reactivity (expected):Chimpanzee, Rat.
Species reactivity (tested):Human and Mouse.

Aufreinigung: Affinity Chromatography on Protein A.

Immunogen: Synthetic peptide corresponding to amino acids 110-125 of Human Jagged-1 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence microscopy andWestern blot. Recommended Dilutions: ELISA: 1/20,000-1/100,000. Western Blot: 1/500-1/2,000. Immunofluorescence: 1/200-1/1,000. Immunohistochemistry on Paraffin Sections: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide, None

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at-20 °C.

Details zu JAG1

Target: JAG1 (Jagged 1 (JAG1))

Andere Bezeichnung: CD339 / JAG1 (JAG1 Produkte)

Synonyme: AGS antikoerper, AHD antikoerper, AWS antikoerper, CD339 antikoerper, HJ1 antikoerper, JAGL1 antikoerper, ABE2 antikoerper, Gsfabe2 antikoerper, Htu antikoerper, Ozz antikoerper, Ser-1 antikoerper, JAG1 antikoerper, jag3 antikoerper, cb243 antikoerper, jag1 antikoerper, sb:cb243 antikoerper, serrateC antikoerper, jagged1 antikoerper, serrate antikoerper, serrate-1 antikoerper, x-serrate-1 antikoerper, jagged 1 antikoerper, jagged 1b antikoerper, jagged 1a antikoerper, jagged 1 L homeolog antikoerper, JAG1 antikoerper, Jag1 antikoerper, jag1 antikoerper, jag1b antikoerper, jag1a antikoerper, jag1.L antikoerper

Hintergrund: Jagged 1 protein encoded by the JAG1 gene, that is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the Jagged 1 protein cause Alagille syndrome. Jagged 1 signaling through notch 1 has also been shown to play a role in hematopoies.Synonyms: JAGL1, Jagged-1, hJ1

Gen-ID: 182

NCBI Accession: NP_000205

UniProt: P78504

Pathways: Notch Signalweg, Stem Cell Maintenance