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CTDSP1 Antikörper (C-Term)

CTDSP1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB5996 unconjugated
Produktnummer ABIN392888
  • Target Alle CTDSP1 Antikörper anzeigen
    CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))
    Bindungsspezifität
    • 14
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 235-261, C-Term
    Reaktivität
    • 39
    • 11
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human
    Wirt
    • 34
    • 3
    • 2
    Kaninchen
    Klonalität
    • 37
    • 2
    Polyklonal
    Konjugat
    • 21
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CTDSP1 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 19
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This CTDSP1-V250 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-261 amino acids from the C-terminal region of human CTDSP1-V250.
    Klon
    RB5996
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))
    Andere Bezeichnung
    CTDSP1 (CTDSP1 Produkte)
    Synonyme
    CTDSP1 antikoerper, NIF3 antikoerper, NLI-IF antikoerper, NLIIF antikoerper, SCP1 antikoerper, fj83f12 antikoerper, im:7141428 antikoerper, wu:fj83f12 antikoerper, zgc:113169 antikoerper, GIP antikoerper, Nif3 antikoerper, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 antikoerper, CTD small phosphatase 1 antikoerper, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antikoerper, CTDSP1 antikoerper, Ctdsp1 antikoerper, ctdsp1 antikoerper, HCAG_04820 antikoerper, CTRG_06220 antikoerper
    Hintergrund
    CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF, 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
    Molekulargewicht
    29203
    Gen-ID
    58190
    NCBI Accession
    NP_001193807, NP_067021, NP_872580
    UniProt
    Q9GZU7
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