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MYLK3 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MYLK3 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN392494

Kurzübersicht für MYLK3 Antikörper (N-Term) (ABIN392494)

Target

Alle MYLK3 Antikörper anzeigen
MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

Reaktivität

  • 46
  • 35
  • 18
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 56
Kaninchen

Klonalität

  • 56
Polyklonal

Konjugat

  • 21
  • 4
  • 4
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MYLK3 Antikörper ist unkonjugiert

Applikation

  • 46
  • 24
  • 22
  • 5
  • 4
  • 4
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB3066
  • Bindungsspezifität

    • 8
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 40-69, N-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This MYLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human MYLK3.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Rossi, Todd, Daniels, Bazan, Belayev: "Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice." in: Journal of neurotrauma, (2015) (PubMed).

    Rossi, Ralay Ranaivo, Patel, Chrzaszcz, Venkatesan, Wainwright: "Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase." in: Journal of neuroscience research, Vol. 89, Issue 6, pp. 852-61, (2011) (PubMed).

  • Target

    MYLK3 (Myosin Light Chain Kinase 3 (MYLK3))

    Andere Bezeichnung

    MYLK3

    Hintergrund

    MLCK, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.

    Molekulargewicht

    88393

    Gen-ID

    91807

    NCBI Accession

    NP_872299

    UniProt

    Q32MK0

    Pathways

    Regulation of Muscle Cell Differentiation
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