PTK7 Antikörper (N-Term)

Produktnummer ABIN392230

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PTK7 in WB, IHC (p) und FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für PTK7 Antikörper (N-Term) (ABIN392230)

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: RB01501

Produktdetails anti-PTK7 Antikörper

Bindungsspezifität: AA 21-52, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCK4 (PTK7) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-52 amino acids from the N-terminal region of human CCK4 (PTK7).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:2000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PTK7 Antikörper (ABIN392230)

Wang, Li, Yin, Wang, Wang, Wei, Guo, Ma, Shi, Zhou, Wang: "PTK7 protein is decreased in epithelial ovarian carcinomas with poor prognosis." in: International journal of clinical and experimental pathology, Vol. 7, Issue 11, pp. 7881-9, (2014) (PubMed).

Details zu PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Andere Bezeichnung: CCK4 (PTK7)

Hintergrund: CCK4 may function as a cell adhesion molecule. Although it belongs to the insuline receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.

Molekulargewicht: 118392

Gen-ID: 5754

NCBI Accession: NP_001257327, NP_002812, NP_690619, NP_690620, NP_690621

UniProt: Q13308

Pathways: RTK Signalweg, Tube Formation