Ret Proto-Oncogene Antikörper (C-Term)

Produktnummer ABIN392039

Der Kaninchen Polyklonal Anti-Ret Proto-Oncogene-Antikörper wurde für WB validiert. Er ist geeignet, Ret Proto-Oncogene in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Ret Proto-Oncogene Antikörper (C-Term) (ABIN392039)

Target: Ret Proto-Oncogene (RET)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ret Proto-Oncogene Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB00707

Produktdetails anti-Ret Proto-Oncogene Antikörper

Bindungsspezifität: AA 1063-1093, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1063-1093 amino acids from the C-terminal region of human RET.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Ret Proto-Oncogene Antikörper (ABIN392039)

de Martimprey, Bertrand, Fusco, Santoro, Couvreur, Vauthier, Malvy: "siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma." in: Nucleic acids research, Vol. 36, Issue 1, pp. e2, (2008) (PubMed).

Details zu Ret Proto-Oncogene

Target: Ret Proto-Oncogene (RET)

Andere Bezeichnung: RET

Hintergrund: RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.

Molekulargewicht: 124319

Gen-ID: 5979

NCBI Accession: NP_065681, NP_066124

UniProt: P07949

Pathways: RTK Signalweg, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation