ERN2 Antikörper (N-Term)

Produktnummer ABIN391194

Produktdetails anti-ERN2 Antikörper

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Bindungsspezifität: AA 39-72, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.

Klon: RB8519

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu ERN2

Target: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Andere Bezeichnung: ERN2 (ERN2 Produkte)

Synonyme: Ire1beta antikoerper, ire1b antikoerper, Ern1 antikoerper, Ire1 antikoerper, Ire1b antikoerper, IRE1-BETA antikoerper, IRE1b antikoerper, endoplasmic reticulum to nucleus signaling 2 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 2 antikoerper, ERN2 antikoerper, ern2 antikoerper, Ern2 antikoerper

Hintergrund: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Molekulargewicht: 102480

Gen-ID: 10595

NCBI Accession: NP_150296

UniProt: Q76MJ5