Ketohexokinase Antikörper (C-Term)

Produktnummer ABIN391089

Dieses Anti-Ketohexokinase-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Ketohexokinase in WB. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für Ketohexokinase Antikörper (C-Term) (ABIN391089)

Target: Ketohexokinase (KHK)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ketohexokinase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB05412

Produktdetails anti-Ketohexokinase Antikörper

Bindungsspezifität: AA 251-281, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Ketohexokinase (KHK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-281 amino acids from the C-terminal region of human Ketohexokinase (KHK).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Ketohexokinase Antikörper (ABIN391089)

Springer, Lindbloom-Hawley, Schermerhorn: "Tissue expression of ketohexokinase in cats." in: Research in veterinary science, Vol. 87, Issue 1, pp. 115-7, (2009) (PubMed).

Diggle, Shires, Leitch, Brooke, Carr, Markham, Hayward, Asipu, Bonthron: "Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 57, Issue 8, pp. 763-74, (2009) (PubMed).

Details zu Ketohexokinase

Target: Ketohexokinase (KHK)

Hintergrund: Ketohexokinase (KHK), or fructokinase, catalyzes conversion of fructose to fructose-1-phosphate. Splice variant 1 is the highly active form found in liver, renal cortex, and small intestine, while splice variant 2 is the lower activity form found in most other tissues. KHK, like glucokinase (GCK) and glucokinase regulator (GCKR), is present in both liver and pancreatic islets. The inhibition of GCK by GCKR is blocked by binding of fructose-1-phosphate to GCKR. The chromosomal proximity of the metabolically connected GCKR and KHK genes has a genetic linkage in type 2 diabetes. Fructosuria, or hepatic fructokinase deficiency, is a benign, asymptomatic defect of intermediary metabolism associated with heterozygosity for G50R and A43T mutations in KHK.

Molekulargewicht: 32523

Gen-ID: 3795

NCBI Accession: NP_000212, NP_006479

UniProt: P50053