MTM1 Antikörper (C-Term)

Produktnummer ABIN390784

Produktdetails anti-MTM1 Antikörper

Target: MTM1 (Myotubularin 1 (MTM1))

Bindungsspezifität: AA 566-594, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.

Klon: RB0856

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MTM1 Antikörper (ABIN390784)

Jian, Cheng, Jiang, Deng, Hu, Zhang: "A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 8, pp. 1904-12, (2007) (PubMed).

Details zu MTM1

Target: MTM1 (Myotubularin 1 (MTM1))

Andere Bezeichnung: MTM1 (MTM1 Produkte)

Synonyme: CNM antikoerper, MTMX antikoerper, XLMTM antikoerper, wu:fb19c01 antikoerper, zgc:123266 antikoerper, myotubularin 1 antikoerper, myotubularin 1 S homeolog antikoerper, MTM1 antikoerper, mtm1 antikoerper, mtm1.S antikoerper, Mtm1 antikoerper

Hintergrund: MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.

Molekulargewicht: 69932

Gen-ID: 4534

NCBI Accession: NP_000243

UniProt: Q13496

Pathways: Inositol Metabolic Process, Skeletal Muscle Fiber Development