MAGEA3 Antikörper (C-Term)

Produktnummer ABIN390107

Der Kaninchen Polyklonal Anti-MAGEA3-Antikörper wurde für WB, FACS und IHC (p) validiert. Er ist geeignet, MAGEA3 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für MAGEA3 Antikörper (C-Term) (ABIN390107)

Target: MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAGEA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB2084

Produktdetails anti-MAGEA3 Antikörper

Bindungsspezifität: AA 283-314, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human MAGEA3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MAGEA3 Antikörper (ABIN390107)

Curioni-Fontecedro, Knights, Tinguely, Nuber, Schneider, Thomson, von Boehmer, Bossart, Pahlich, Gehring, Moch, Renner, Knuth, Zippelius: "MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma." in: Leukemia, Vol. 22, Issue 8, pp. 1646-8, (2008) (PubMed).

Dubovsky, Albertini, McNeel: "MAD-CT-2 identified as a novel melanoma cancer-testis antigen using phage immunoblot analysis." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 30, Issue 7, pp. 675-83, (2007) (PubMed).

Kondo, Zhu, Asa, Ezzat: "The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4713-20, (2007) (PubMed).

Details zu MAGEA3

Target: MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))

Andere Bezeichnung: MAGEA3

Hintergrund: MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80 % sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.

Molekulargewicht: 34747

Gen-ID: 4102

NCBI Accession: NP_005353

UniProt: P43357