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EDG4 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EDG4 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.
Produktnummer ABIN390085

Kurzübersicht für EDG4 Antikörper (N-Term) (ABIN390085)

Target

Alle EDG4 (LPAR2) Antikörper anzeigen
EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Reaktivität

  • 49
  • 37
  • 30
  • 3
Human

Wirt

  • 66
  • 1
Kaninchen

Klonalität

  • 67
Polyklonal

Konjugat

  • 25
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser EDG4 Antikörper ist unkonjugiert

Applikation

  • 26
  • 23
  • 22
  • 16
  • 13
  • 10
  • 9
  • 8
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB1827
  • Bindungsspezifität

    • 16
    • 7
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 3-32, N-Term

    Homologie

    Pr

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This EDG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human EDG4.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Yamauchi, Yamamura, Katase, Itadani, Okada, Kobiki, Nakamura, Yamaguchi, Kuribayashi: "Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device." in: BMC cancer, Vol. 17, Issue 1, pp. 234, (2017) (PubMed).

    Geng, Lan, Singha, Gilchrist, Weinreb, Violette, Weinberg, Saikumar, Venkatachalam: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." in: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).

    Bernhart, Kollroser, Rechberger, Reicher, Heinemann, Schratl, Hallström, Wintersperger, Nusshold, DeVaney, Zorn-Pauly, Malli, Graier, Malle, Sattler: "Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture." in: Proteomics, Vol. 10, Issue 1, pp. 141-58, (2010) (PubMed).

    Todorova, Fuentes, Soria, Nadal, Quesada: "Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway." in: Cellular signalling, Vol. 21, Issue 4, pp. 523-8, (2009) (PubMed).

    Horak, Lee, Elkahloun, Boissan, Dumont, Maga, Arnaud-Dabernat, Palmieri, Stetler-Stevenson, Lacombe, Meltzer, Steeg: "Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2." in: Cancer research, Vol. 67, Issue 15, pp. 7238-46, (2007) (PubMed).

  • Target

    EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

    Andere Bezeichnung

    EDG4

    Hintergrund

    EDG4 is a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.

    Molekulargewicht

    39084

    Gen-ID

    9170

    NCBI Accession

    NP_004711

    UniProt

    Q9HBW0
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