GREM1 Antikörper (C-Term)

Produktnummer ABIN390078

Dieses Anti-GREM1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GREM1 in WB. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 9+ Publikationen zitiert.

Kurzübersicht für GREM1 Antikörper (C-Term) (ABIN390078)

Target: GREM1 (Gremlin 1 (GREM1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GREM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB2060

Produktdetails anti-GREM1 Antikörper

Bindungsspezifität: AA 147-175, C-Term

Homologie: Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GREMLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of mouse GREMLIN.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-GREM1 Antikörper (ABIN390078)

Staloch, Gao, Liu, Xu, Feng, Aronson, Falzon, Greeley, Rastellini, Chao, Hellmich, Cao, Ko: "Gremlin is a key pro-fibrogenic factor in chronic pancreatitis." in: Journal of molecular medicine (Berlin, Germany), (2015) (PubMed).

Droguett, Krall, Burgos, Valderrama, Carpio, Ardiles, Rodriguez-Diez, Kerr, Walz, Ruiz-Ortega, Egido, Mezzano: "Tubular overexpression of gremlin induces renal damage susceptibility in mice." in: PLoS ONE, Vol. 9, Issue 7, pp. e101879, (2014) (PubMed).

Ahn, Mercado, Laé, Ladanyi: "Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma." in: Oncology reports, Vol. 30, Issue 2, pp. 968-78, (2013) (PubMed).

Gelse, Ekici, Cipa, Swoboda, Carl, Olk, Hennig, Klinger: "Molecular differentiation between osteophytic and articular cartilage--clues for a transient and permanent chondrocyte phenotype." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 20, Issue 2, pp. 162-71, (2012) (PubMed).

Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: "Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 24, Issue 4, pp. 1121-9, (2009) (PubMed).

Carvajal, Droguett, Burgos, Aros, Ardiles, Flores, Carpio, Ruiz-Ortega, Egido, Mezzano: "Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy." in: Transplantation proceedings, Vol. 40, Issue 3, pp. 734-9, (2008) (PubMed).

Mezzano, Droguett, Burgos, Aros, Ardiles, Flores, Carpio, Carvajal, Ruiz-Ortega, Egido: "Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 22, Issue 7, pp. 1882-90, (2007) (PubMed).

Wordinger, Fleenor, Hellberg, Pang, Tovar, Zode, Fuller, Clark: "Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma." in: Investigative ophthalmology & visual science, Vol. 48, Issue 3, pp. 1191-200, (2007) (PubMed).

Frank, Kho, Schatton, Murphy, Molloy, Zhan, Ramoni, Frank, Kohane, Gussoni: "Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin." in: The Journal of cell biology, Vol. 175, Issue 1, pp. 99-110, (2006) (PubMed).

Details zu GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Andere Bezeichnung: GREMLIN

Hintergrund: GREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.

Molekulargewicht: 20710

Gen-ID: 23892

NCBI Accession: NP_035954

UniProt: O70326

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location