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RAPTOR Antikörper (pSer863)

RAPTOR Reaktivität: Human WB, DB, IHC (p) Wirt: Kaninchen Polyclonal RB24817-24818 unconjugated
Produktnummer ABIN389879
  • Target Alle RAPTOR Antikörper anzeigen
    RAPTOR
    Bindungsspezifität
    • 15
    • 15
    • 15
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer863
    Reaktivität
    • 63
    • 45
    • 25
    • 15
    • 1
    Human
    Wirt
    • 63
    • 3
    Kaninchen
    Klonalität
    • 62
    • 4
    Polyklonal
    Konjugat
    • 21
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser RAPTOR Antikörper ist unkonjugiert
    Applikation
    • 30
    • 26
    • 26
    • 26
    • 8
    • 8
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Raptor Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.
    Klon
    RB24817-24818
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:500. IHC-P: 1:100. DB: 1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Cully, Genevet, Warne, Treins, Liu, Bastien, Baum, Tapon, Leevers, Downward: "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1." in: Molecular and cellular biology, Vol. 30, Issue 2, pp. 481-95, (2009) (PubMed).

  • Target
    RAPTOR
    Andere Bezeichnung
    Raptor (RAPTOR Produkte)
    Synonyme
    KOG1 antikoerper, Mip1 antikoerper, 4932417H02Rik antikoerper, Rap antikoerper, Raptor antikoerper, mKIAA1303 antikoerper, RGD1311784 antikoerper, regulatory associated protein of MTOR complex 1 antikoerper, regulatory associated protein of MTOR, complex 1 antikoerper, RPTOR antikoerper, Rptor antikoerper
    Hintergrund
    Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
    Molekulargewicht
    149038
    Gen-ID
    57521
    NCBI Accession
    NP_065812
    UniProt
    Q8N122
    Pathways
    Warburg Effekt
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