RAPTOR Antikörper (pSer863)

Produktnummer ABIN389879

Der Kaninchen Polyklonal Anti-RAPTOR-Antikörper wurde für WB, DB und IHC (p) validiert. Er ist geeignet, RAPTOR in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für RAPTOR Antikörper (pSer863) (ABIN389879)

Target: RAPTOR

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAPTOR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB24817-24818

Produktdetails anti-RAPTOR Antikörper

Bindungsspezifität: pSer863

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Raptor Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:500. IHC-P: 1:100. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-RAPTOR Antikörper (ABIN389879)

Cully, Genevet, Warne, Treins, Liu, Bastien, Baum, Tapon, Leevers, Downward: "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1." in: Molecular and cellular biology, Vol. 30, Issue 2, pp. 481-95, (2009) (PubMed).

Details zu RAPTOR

Target: RAPTOR

Andere Bezeichnung: Raptor

Hintergrund: Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.

Molekulargewicht: 149038

Gen-ID: 57521

NCBI Accession: NP_065812

UniProt: Q8N122

Pathways: Warburg Effekt