RAD9A Antikörper (pSer387)

Produktnummer ABIN389638

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RAD9A in IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für RAD9A Antikörper (pSer387) (ABIN389638)

Target: RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD9A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB29523

Produktdetails anti-RAD9A Antikörper

Bindungsspezifität: pSer387

Homologie: Pr

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RAD9 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S387 of human RAD9.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-RAD9A Antikörper (ABIN389638)

Mohni, Dee, Smith, Schumacher, Weller: "Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins." in: Journal of virology, Vol. 87, Issue 1, pp. 531-42, (2012) (PubMed).

Xu, Vaithiyalingam, Glick, Mordes, Chazin, Cortez: "The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling." in: Molecular and cellular biology, Vol. 28, Issue 24, pp. 7345-53, (2008) (PubMed).

Details zu RAD9A

Target: RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))

Andere Bezeichnung: RAD9

Hintergrund: Rad9 is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade.

Molekulargewicht: 42547

Gen-ID: 5883

NCBI Accession: NP_001230153, NP_004575

UniProt: Q99638

Pathways: Positive Regulation of Response to DNA Damage Stimulus