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Androgen Receptor Antikörper (AA 365-392)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Androgen Receptor in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN389077

Kurzübersicht für Androgen Receptor Antikörper (AA 365-392) (ABIN389077)

Target

Alle Androgen Receptor (AR) Antikörper anzeigen
Androgen Receptor (AR)

Reaktivität

  • 311
  • 97
  • 93
  • 29
  • 17
  • 17
  • 15
  • 12
  • 8
  • 4
  • 4
  • 3
  • 1
Human, Maus

Wirt

  • 257
  • 62
  • 1
  • 1
  • 1
Kaninchen

Klonalität

  • 241
  • 79
Polyklonal

Konjugat

  • 133
  • 27
  • 11
  • 11
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 5
  • 5
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser Androgen Receptor Antikörper ist unkonjugiert

Applikation

  • 191
  • 80
  • 71
  • 65
  • 53
  • 42
  • 27
  • 23
  • 23
  • 22
  • 19
  • 19
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB2579
  • Bindungsspezifität

    • 23
    • 22
    • 20
    • 19
    • 17
    • 17
    • 15
    • 13
    • 11
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 365-392

    Homologie

    Pr, Pig

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Target

    Androgen Receptor (AR)

    Andere Bezeichnung

    Androgen Receptor (ANDR)

    Hintergrund

    Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor, sumoylation of ANDR represses androgen receptor dependent transcription.

    Molekulargewicht

    99188

    Gen-ID

    367

    NCBI Accession

    NP_000035, NP_001011645

    UniProt

    P10275

    Pathways

    Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
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