USP4 Antikörper (C-Term)

Produktnummer ABIN388883

Der Kaninchen Polyklonal Anti-USP4-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, USP4 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für USP4 Antikörper (C-Term) (ABIN388883)

Target: USP4 (Ubiquitin Specific Peptidase 4 (USP4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB4269

Produktdetails anti-USP4 Antikörper

Bindungsspezifität: AA 903-933, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This USP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 903-933 amino acids from the C-terminal region of human USP4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-USP4 Antikörper (ABIN388883)

Laurell, Velázquez-Fernández, Lindsten, Juhlin, Enberg, Geli, Höög, Kjellman, Lundeberg, Hamberger, Larsson, Nilsson, Bäckdahl: "Transcriptional profiling enables molecular classification of adrenocortical tumours." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 1, pp. 141-52, (2009) (PubMed).

Details zu USP4

Target: USP4 (Ubiquitin Specific Peptidase 4 (USP4))

Andere Bezeichnung: USP4

Hintergrund: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Molekulargewicht: 108565

Gen-ID: 7375

NCBI Accession: NP_001238806, NP_003354, NP_955475

UniProt: Q13107