GABARAP Antikörper (AA 1-30)

Produktnummer ABIN2849716

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GABARAP in WB, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für GABARAP Antikörper (AA 1-30) (ABIN2849716)

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABARAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB11846

Produktdetails anti-GABARAP Antikörper

Bindungsspezifität: AA 1-30

Homologie: B, Rb

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GABARAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids of human GABARAP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF: 1:25. IF: 1:25. WB: 1:1000-1 :2000. IHC-P: 1:25. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-GABARAP Antikörper (ABIN2849716)

Joachim, Razi, Judith, Wirth, Calamita, Encheva, Dynlacht, Snijders, OReilly, Jefferies, Tooze: "Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy." in: Current biology : CB, Vol. 27, Issue 14, pp. 2123-2136.e7, (2018) (PubMed).

Clough, Wright, Pereira, Hirst, Johnston, Henriques, Frickel: "K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells." in: PLoS pathogens, Vol. 12, Issue 11, pp. e1006027, (2017) (PubMed).

Egan, Chun, Vamos, Zou, Rong, Miller, Lou, Raveendra-Panickar, Yang, Sheffler, Teriete, Asara, Turk, Cosford, Shaw: "Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates." in: Molecular cell, Vol. 59, Issue 2, pp. 285-97, (2015) (PubMed).

Orfali, ODonovan, Nyhan, Britschgi, Tschan, Cahill, Mongan, Gudas, McKenna: "Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation." in: Experimental hematology, Vol. 43, Issue 9, pp. 781-93.e2, (2015) (PubMed).

Details zu GABARAP

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Andere Bezeichnung: GABARAP

Hintergrund: Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. GABARAP is GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.

Molekulargewicht: 13918

Gen-ID: 11337

NCBI Accession: NP_009209

UniProt: O95166

Pathways: Autophagie