Beclin 1 Antikörper (AA 181-210)

Produktnummer ABIN388545

Dieses Anti-Beclin 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Beclin 1 in WB und IHC (p). Geeignet für Human und Maus. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für Beclin 1 Antikörper (AA 181-210) (ABIN388545)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Beclin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB7461

Produktdetails anti-Beclin 1 Antikörper

Bindungsspezifität: AA 181-210

Homologie: B, C

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Beclin 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from human Beclin 1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Beclin 1 Antikörper (ABIN388545)

Li, Zhou, Yang, Li, Zhang, Zheng: "Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells." in: Oncology reports, Vol. 37, Issue 6, pp. 3459-3466, (2018) (PubMed).

Zhang, Yi, Ko, Kim, Seo, Lee, Lee, Kim: "Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain." in: Brain research, Vol. 1519, pp. 31-9, (2013) (PubMed).

Liu, He, von Rütte, Yousefi, Hunger, Simon: "Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma." in: Science translational medicine, Vol. 5, Issue 202, pp. 202ra123, (2013) (PubMed).

Thyagarajan, Jedinak, Nguyen, Terry, Baldridge, Jiang, Sliva: "Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)." in: Nutrition and cancer, Vol. 62, Issue 5, pp. 630-40, (2010) (PubMed).

Bohensky, Leshinsky, Srinivas, Shapiro: "Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression." in: Pediatric nephrology (Berlin, Germany), Vol. 25, Issue 4, pp. 633-42, (2010) (PubMed).

Details zu Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Andere Bezeichnung: Beclin 1

Hintergrund: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.

Molekulargewicht: 51896

Gen-ID: 8678

NCBI Accession: NP_003757

UniProt: Q14457

Pathways: Autophagie