BCL2A1 Antikörper (Ala1)

Produktnummer ABIN388092

Dieses Anti-BCL2A1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BCL2A1 in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für BCL2A1 Antikörper (Ala1) (ABIN388092)

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB1251

Produktdetails anti-BCL2A1 Antikörper

Bindungsspezifität: AA 30-65, Ala1

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BCL2A1 (A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-65 amino acids from human BCL2A1 (A1).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-BCL2A1 Antikörper (ABIN388092)

Gollob, Sciambi, Huang, Dressman: "Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma." in: Cancer research, Vol. 65, Issue 19, pp. 8869-77, (2005) (PubMed).

Details zu BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Andere Bezeichnung: BCL2A1

Hintergrund: Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

Molekulargewicht: 20132

Gen-ID: 597

NCBI Accession: NP_001108207, NP_004040

UniProt: Q16548