Ubiquitin Antikörper (AA 36-66)

Produktnummer ABIN388040

Produktdetails anti-Ubiquitin Antikörper

Target: Ubiquitin (Ub)

Bindungsspezifität: AA 36-66

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ubiquitin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Y, B, E, D, Pr, M, Pig, Rat, Sh, C, Hs, Ha, X, Rb

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Ubiquitin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-66 amino acids of human Ubiquitin.

Klon: RB2702

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Ubiquitin Antikörper (ABIN388040)

Huang, Wang, Wright, Yang, Zhou, Li, Yang, Small, Parmacek: "Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 14, pp. 4447-52, (2015) (PubMed).

Vernes, Nicod, Elahi, Coventry, Kenny, Coupe, Bird, Davies, Fisher: "Functional genetic analysis of mutations implicated in a human speech and language disorder." in: Human molecular genetics, Vol. 15, Issue 21, pp. 3154-67, (2006) (PubMed).

Details zu Ubiquitin

Target: Ubiquitin (Ub)

Andere Bezeichnung: Ubiquitin (Ub Produkte)

Hintergrund: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.

Molekulargewicht: 77039

Gen-ID: 7314

UniProt: P0CG48

Pathways: Mitotic G1-G1/S Phases, Ubiquitin Proteasome Pathway