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LSD1 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LSD1 in WB, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN388021

Kurzübersicht für LSD1 Antikörper (N-Term) (ABIN388021)

Target

Alle LSD1 (KDM1A) Antikörper anzeigen
LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Reaktivität

  • 76
  • 36
  • 30
  • 5
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 62
  • 14
  • 1
Kaninchen

Klonalität

  • 58
  • 20
Polyklonal

Konjugat

  • 58
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LSD1 Antikörper ist unkonjugiert

Applikation

  • 70
  • 38
  • 30
  • 24
  • 16
  • 13
  • 13
  • 13
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB7579-RB7580
  • Bindungsspezifität

    • 15
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 108-142, N-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This LSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-142 amino acids from the N-terminal region of human LSD1.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Target

    LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

    Andere Bezeichnung

    LSD1

    Hintergrund

    LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.

    Molekulargewicht

    92903

    Gen-ID

    23028

    NCBI Accession

    NP_001009999, NP_055828

    UniProt

    O60341

    Pathways

    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effekt
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