JMJD4 Antikörper (C-Term)

Produktnummer ABIN387875

Produktdetails anti-JMJD4 Antikörper

Target: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Bindungsspezifität: AA 423-455, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JMJD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-455 amino acids from the C-terminal region of human JMJD4.

Klon: RB10802

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu JMJD4

Target: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Andere Bezeichnung: JMJD4 (JMJD4 Produkte)

Synonyme: JMJD4 antikoerper, 6430559I23 antikoerper, RGD1307186 antikoerper, jumonji domain containing 4 antikoerper, jumonji domain containing 4 L homeolog antikoerper, JMJD4 antikoerper, jmjd4.L antikoerper, Jmjd4 antikoerper

Hintergrund: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Molekulargewicht: 52493

Gen-ID: 65094

NCBI Accession: NP_001154937, NP_075383

UniProt: Q9H9V9