PRDM2 Antikörper (AA 1-347)

Produktnummer ABIN387783

Zitiert in 2+ Publikationen. Der Maus Monoklonal anti-PRDM2 Antikörper (Klon 33AT1045) (ABIN387783) detektiert spezifisch PRDM2 in WB und ChIP. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für PRDM2 Antikörper (AA 1-347) (ABIN387783)

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRDM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Klon: 33AT1045

Produktdetails anti-PRDM2 Antikörper

Bindungsspezifität: AA 1-347

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: CHIP: 1:100. CHIP: 1:100. CHIP: 1:100. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PRDM2 Antikörper (ABIN387783)

Lakshmikuttyamma, Takahashi, Pastural, Torlakovic, Amin, Garcia-Manero, Voralia, Czader, DeCoteau, Geyer: "RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression." in: Journal of hematology & oncology, Vol. 2, pp. 28, (2009) (PubMed).

Carling, Kim, Yang, Gu, Zhang, Huang: "A histone methyltransferase is required for maximal response to female sex hormones." in: Molecular and cellular biology, Vol. 24, Issue 16, pp. 7032-42, (2004) (PubMed).

Details zu PRDM2

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Andere Bezeichnung: PRDM2 (RIZ1)

Hintergrund: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 188915

Gen-ID: 7799

NCBI Accession: NP_001007258, NP_001129082, NP_036363, NP_056950

UniProt: Q13029