IL2 Receptor beta Antikörper

Produktnummer ABIN376384

Dieser Ratte Monoklonal Antikörper detektiert spezifisch IL2 Receptor beta in FACS und IP. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für IL2 Receptor beta Antikörper (ABIN376384)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser IL2 Receptor beta Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP)

Klon: 5H4

Produktdetails anti-IL2 Receptor beta Antikörper

Verwendungszweck: Rat Anti-Mouse CD122-LE/AF

Spezifität: Mouse CD122, 90-100 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD122 antibody for use in flow cytometry and immunoprecipitation assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-m-beta-t-28)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Andere Bezeichnung: CD122

Hintergrund: The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity, (ii) the β chain that binds IL-2 with high affinity, and (ii) the common γ chain ( γ C ) that does not bind IL-2. The high affinity receptor complex is an α / β / γ heterotrimer with a K d of 1.3 x 10 -11 M. In mouse spleen, CD122 is expresed on approx. 30 % of CD8 + cells and all NK cells, but < 1 % of B cells and CD4 + T lymphocytes. In the thymus, its expression is confined to CD4 - CD8 + single positive and CD4 - CD8 - double negative cells. Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes.

Gen-ID: 16185

UniProt: P16297

Pathways: JAK-STAT Signalweg, Growth Factor Binding