IL2 Receptor beta Antikörper (Biotin)

Produktnummer ABIN375945

Dieses Anti-IL2 Receptor beta-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von IL2 Receptor beta in FACS. Geeignet für Maus.

Kurzübersicht für IL2 Receptor beta Antikörper (Biotin) (ABIN375945)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser IL2 Receptor beta Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: 5H4

Produktdetails anti-IL2 Receptor beta Antikörper (Biotin)

Spezifität: Mouse CD122, 90-100 kDa

Produktmerkmale: Rat Anti-Mouse CD122-BIOT

Aufreinigung: Purified

Immunogen: Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-mbetat-28)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

• Applications: FC - Quality tested , IP - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE and APC conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg in 1.0 mL of PBS/Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Details zu IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Andere Bezeichnung: CD122

Hintergrund: The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity, (ii) the β chain that binds IL-2 with high affinity, and (ii) the common γ chain ( γ C ) that does not bind IL-2. The high affinity receptor complex is an α / β / γ heterotrimer with a K d of 1.3 x 10 -11 M. 2 In mouse spleen, CD122 is expresed on approx. 30 % of CD8 + cells and all NK cells, but < 1 % of B cells and CD4 + T lymphocytes. In the thymus, its expression is confined to CD4 - CD8 + single positive and CD4 - CD8 - double negative cells. 4 Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes.

Pathways: JAK-STAT Signalweg, Growth Factor Binding