LAMP1 Antikörper (Biotin)

Produktnummer ABIN375425

Der Maus Monoklonal Anti-LAMP1-Antikörper wurde für FACS und IHC validiert. Er ist geeignet, LAMP1 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für LAMP1 Antikörper (Biotin) (ABIN375425)

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAMP1 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC)

Klon: H4A3

Produktdetails anti-LAMP1 Antikörper (Biotin)

Spezifität: Human/Rhesus/African Green Monkey/Pigtail Macaque/Sooty Mangabey CD107a, Mr 100-120 kDa

Produktmerkmale: Mouse Anti-Human CD107a-BIOT

Aufreinigung: Purified

Immunogen: Human adherent peripheral blood cells

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Working Dilution:
10 µL/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Handhabung: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Referenzen für anti-LAMP1 Antikörper (Biotin) (ABIN375425)

Hershkovitz, Rosental, Rosenberg, Navarro-Sanchez, Jivov, Zilka, Gershoni-Yahalom, Brient-Litzler, Bedouelle, Ho, Campbell, Rager-Zisman, Despres, Porgador: "NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 4, pp. 2610-21, (2009) (PubMed).

Details zu LAMP1

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Andere Bezeichnung: CD107a

Hintergrund: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.

Pathways: Autophagie