SIGLEC8 Antikörper (Internal Region)

Produktnummer ABIN375053

Es gibt 1 Publikation für dieses Produkt. Der Ziege Polyklonal anti-SIGLEC8 Antikörper wird verwendet zum Nachweis von SIGLEC8 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für SIGLEC8 Antikörper (Internal Region) (ABIN375053)

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SIGLEC8 Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody reacts to SIGLEC8.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-SYKSQLNYKTKQ, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-SIGLEC8 Antikörper (ABIN375053)

Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).

Details zu SIGLEC8

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Andere Bezeichnung: CD329 / SIGLEC8

Hintergrund: SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.Synonyms: CDw329, SAF2, Sialic acid-binding Ig-like lectin 8, Sialoadhesin family member 2, Siglec-8

Gen-ID: 27181, 9606

UniProt: Q9NYZ4