AICDA Antikörper (N-Term)

Produktnummer ABIN374978

Der Ziege Polyklonal anti-AICDA Antikörper wird verwendet zum Nachweis von AICDA in Proben von Human, Rind (Kuh) und Schwein. Er wurde validiert für WB und EIA.

Kurzübersicht für AICDA Antikörper (N-Term) (ABIN374978)

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Reaktivität: Human, Rind (Kuh), Schwein

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser AICDA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-AICDA Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to AID.

Kreuzreaktivität (Details): Species reactivity (expected):Pig, Cow.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence RRKFLYQFKNVR-C, from the N Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/1000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu AICDA

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Andere Bezeichnung: AICDA / AID

Hintergrund: AID or AICDA (activation-induced cytidine deaminase) is an RNA editing deaminase involved in somatic hypermutation, gene conversion, and class switch recombination. Expression of AID is restricted to stimulated B lymphocytes and it is required for several crucial steps of B cell terminal differentiation necessary for efficient antibody responses. It catalyses the deamination of Cytidine to uridine and ammonia and is strongly expressed in lymph nodes and tonsils. Defects in AICDA are the cause of autosomal recessive hyper IgM immunodeficiency syndrome type 2 (HIGM2) which is characterized by normal or elevated serum IgM levels with the absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections.Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase

Gen-ID: 57379, 9606

UniProt: Q9GZX7

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response