AICDA Antikörper (C-Term)

Produktnummer ABIN499233

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-AICDA Antikörper (ABIN499233) detektiert spezifisch AICDA in WB, IF und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für AICDA Antikörper (C-Term) (ABIN499233)

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AICDA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-AICDA Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody recognizes AID (C-term).

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: A Peptide corresponding to 14 amino acids near the carboxy-terminus of Human AID

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: AID antibody can be used for detection of AID at 1 - 2 μg/mL. Whole cell lysatefrom Ramos cells can be used as positive control. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-AICDA Antikörper (ABIN499233)

Milillo, Molinario, Costanzi, Vischini, La Carpia, La Greca, Rigante, Gambaro, Gurrieri, Sangiorgi: "Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura." in: Journal of nephrology, Vol. 31, Issue 5, pp. 731-741, (2018) (PubMed).

Details zu AICDA

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Andere Bezeichnung: AICDA / AID

Hintergrund: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase

Gen-ID: 57379

NCBI Accession: NP_065712

UniProt: Q9GZX7

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response