Neuregulin 3 Antikörper (C-Term)

Produktnummer ABIN374780

Der Ziege Polyklonal anti-Neuregulin 3 Antikörper wird verwendet zum Nachweis von Neuregulin 3 in Proben von Human, Maus, Ratte und Hund. Er wurde validiert für WB.

Kurzübersicht für Neuregulin 3 Antikörper (C-Term) (ABIN374780)

Target: Neuregulin 3 (NRG3)

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Neuregulin 3 Antikörper

Bindungsspezifität: C-Term

Sequenz: C-RNEIQRDSAL TK

Spezifität: This antibody recognizes Neuregulin 3.

Kreuzreaktivität (Details): Species reactivity (expected):Canine.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_001010848.2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/64000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Neuregulin 3

Target: Neuregulin 3 (NRG3)

Andere Bezeichnung: Neuregulin 3

Hintergrund: NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization. There are 4 different isoforms.Synonyms: NRG3, Pro-NRG3, Pro-neuregulin-3, membrane-bound isoform

Molekulargewicht: 75.0 kDa (NP_001010848.2).

Gen-ID: 10718

NCBI Accession: NP_001010848

UniProt: P56975

Pathways: RTK Signalweg