PAI1 Antikörper (Internal Region)

Produktnummer ABIN374547

Zitiert in 1 Publikation. Der Ziege Polyklonal anti-PAI1 Antikörper (ABIN374547) detektiert spezifisch PAI1 in WB, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Hund.

Kurzübersicht für PAI1 Antikörper (Internal Region) (ABIN374547)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reaktivität: Human, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-PAI1 Antikörper

Bindungsspezifität: Internal Region

Sequenz: C-GFKIDDKGMA PALRH

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Synthetic peptide (C-GFKIDDKGMAPALRH) from the internal region of SERPINE1 (NP_000593.1, NP_001158885.1). Genename: SERPINE1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-PAI1 Antikörper (ABIN374547)

Cipollone, Felicioni, Sarzani, Ucchino, Spigonardo, Mandolini, Malatesta, Bucci, Mammarella, Santovito, de Lutiis, Marchetti, Mezzetti, Buttitta: "A unique microRNA signature associated with plaque instability in humans." in: Stroke, Vol. 42, Issue 9, pp. 2556-63, (2011) (PubMed).

Details zu PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Andere Bezeichnung: SERPINE1 / PAI1

Hintergrund: PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1

Molekulargewicht: 45.1 kDa (NP_000593.1)

NCBI Accession: NM_000602

UniProt: P05121

Pathways: p53 Signalweg, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagie, Smooth Muscle Cell Migration