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DKK2 Antikörper (C-Term)

Dieses Anti-DKK2-Antikörper ist ein Ziege Polyklonal-Antikörper zur Detektion von DKK2 in WB. Geeignet für Human, Maus, Ratte, Hund und Rind (Kuh).
Produktnummer ABIN374181

Kurzübersicht für DKK2 Antikörper (C-Term) (ABIN374181)

Target

Alle DKK2 Antikörper anzeigen
DKK2 (Dickkopf 2 Homolog (DKK2))

Reaktivität

  • 56
  • 15
  • 4
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Hund, Rind (Kuh)

Wirt

  • 50
  • 5
  • 1
Ziege

Klonalität

  • 51
  • 5
Polyklonal

Konjugat

  • 31
  • 8
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DKK2 Antikörper ist unkonjugiert

Applikation

  • 44
  • 28
  • 24
  • 7
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 8
    • 8
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody detects Dickkopf-2 at C-term.

    Kreuzreaktivität (Details)

    Species reactivity (expected):Mouse, Rat, Canine, Bovine.
    Species reactivity (tested):Human.

    Aufreinigung

    Affinity chromatography

    Immunogen

    Peptide with sequence ATYSSKARLHVCQKI, from the C Terminus of the protein sequence Genename: DKK2
  • Applikationshinweise

    Peptide ELISA: 1/8000. Western blot: 1 - 3 μg/mL. Approx 28 kDa band observed in Human Heart lysate (calculatedMW of 28.8 kDa according to NP_055236).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.5 mg/mL

    Buffer

    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    DKK2 (Dickkopf 2 Homolog (DKK2))

    Andere Bezeichnung

    Dickkopf-2 (DKK2)

    Hintergrund

    Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.Synonyms: Dickkopf-related protein 2, Dkk-2

    Gen-ID

    27123

    NCBI Accession

    NP_055236

    UniProt

    Q9UBU2

    Pathways

    WNT Signalweg
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