IL7R Antikörper (pTyr449)

Produktnummer ABIN372989

Der Kaninchen Polyklonal anti-IL7R Antikörper wird verwendet zum Nachweis von IL7R in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für IL7R Antikörper (pTyr449) (ABIN372989)

Target: IL7R (Interleukin 7 Receptor (IL7R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL7R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-IL7R Antikörper

Bindungsspezifität: pTyr449

Spezifität: This antibody recognizes Interleukin 7 Receptor Alpha Chain (IL7R). This phospho-specific polyclonal antibody reacts with Mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide corresponding to residues near Tyr449 of Mouse IL-7 protein

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 5 μg/mL. Western blot: 1/1000 - 1/10000. ELISA: 1/100000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, pH 7.2 with 0.15 M Sodium Chloride, 0.01 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Andere Bezeichnung: CD127 / IL7R

Hintergrund: Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7). The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).Synonyms: IL-7R-alpha, IL7 receptor alpha, Interleukin-7 receptor subunit alpha

Gen-ID: 3575

NCBI Accession: NP_002176

UniProt: P16871

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size