TAO Kinase 2 Antikörper (pSer181)

Produktnummer ABIN372726

Der Kaninchen Polyklonal anti-TAO Kinase 2 Antikörper (ABIN372726) detektiert spezifisch TAO Kinase 2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Xenopus laevis, Fink und Zebrafisch (Danio rerio).

Kurzübersicht für TAO Kinase 2 Antikörper (pSer181) (ABIN372726)

Target: TAO Kinase 2 (TAOK2)

Reaktivität: Human, Maus, Ratte, Hund, Xenopus laevis, Fink, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAO Kinase 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TAO Kinase 2 Antikörper

Bindungsspezifität: pSer181

Spezifität: Specific for the ~120k TAO2 phosphorylated at Ser181 in Western blots. Immunolabeling is completely eliminated by treatment with lambda-phosphatase.

Kreuzreaktivität (Details): Species reactivity (expected):Canine, Finch, Xenopus and Zebrafish.
Species reactivity (tested):Human, Mouse and Rat.

Aufreinigung: Affinity Chromatography via sequential chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser181 of TAO2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu TAO Kinase 2

Target: TAO Kinase 2 (TAOK2)

Hintergrund: In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999, Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.Synonyms: KFC-C, KIAA0881, Kinase from chicken homolog C, MAP3K17, PSK-1, PSK1, Prostate-derived STE20-like kinase 1, Serine/threonine-protein kinase TAO2, Thousand and one amino acid protein 2, UNQ2971/PRO7431

Gen-ID: 9344

NCBI Accession: NP_004774

UniProt: Q9UL54

Pathways: Cell-Cell Junction Organization