SYN1 Antikörper (pSer603)

Produktnummer ABIN372721

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SYN1 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Rind (Kuh), Xenopus laevis und Zebrafisch (Danio rerio).

Kurzübersicht für SYN1 Antikörper (pSer603) (ABIN372721)

Target: SYN1 (Synapsin I (SYN1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Xenopus laevis, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SYN1 Antikörper

Bindungsspezifität: pSer603

Spezifität: This antibody recognizes ~78k Synapsin I doublet protein phosphorylated at Ser603. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Bovine, Mouse, Xenopus and Zebrafish.
Species reactivity (tested):Rat.

Aufreinigung: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser603 of Synapsin I.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu SYN1

Target: SYN1 (Synapsin I (SYN1))

Andere Bezeichnung: Synapsin-1

Hintergrund: Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Serine 603 is the site on synapsin I that is phosphorylated by calcium calmodulin kinase II and by p21-activated kinases (Sakurada et al., 2002, Czernik et al., 1987). Phosphorylation of this site is thought to regulate synaptic vesicle function (Nayak et al., 1996, Bahler and Greengard, 1987, McGuinness et al., 1989).Synonyms: Brain protein 4.1, SYN1, Synapsin I

Gen-ID: 6853

NCBI Accession: NP_008881

UniProt: P17600