SYN1 Antikörper (pSer549)

Produktnummer ABIN372720

Dieses Anti-SYN1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SYN1 in WB, IHC (fro) und DB. Geeignet für Human, Ratte, Maus, Rind (Kuh), Hund und Non-Human Primate.

Kurzübersicht für SYN1 Antikörper (pSer549) (ABIN372720)

Target: SYN1 (Synapsin I (SYN1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Non-Human Primate

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB)

Produktdetails anti-SYN1 Antikörper

Bindungsspezifität: pSer549

Spezifität: This antibody recognizes the ~78k Synapsin I doublet protein phosphorylated at Ser549. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Bovine, Canine, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

Aufreinigung: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser549 of Synapsin I.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1,000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu SYN1

Target: SYN1 (Synapsin I (SYN1))

Andere Bezeichnung: Synapsin-1

Hintergrund: Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking.Synonyms: Brain protein 4.1, SYN1, Synapsin I

Gen-ID: 6853

NCBI Accession: NP_008881

UniProt: P17600