Metabotropic Glutamate Receptor 1 Antikörper (C-Term)

Produktnummer ABIN372668

Der Kaninchen Polyklonal anti-Metabotropic Glutamate Receptor 1 Antikörper wird verwendet zum Nachweis von Metabotropic Glutamate Receptor 1 in Proben von Ratte. Er wurde validiert für WB und IHC (fro).

Kurzübersicht für Metabotropic Glutamate Receptor 1 Antikörper (C-Term) (ABIN372668)

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Metabotropic Glutamate Receptor 1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody is specific for the ~125k monomer and the ~250k mGluR1a dimer. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.

Kreuzreaktivität (Details): Species reactivity (tested):Rat.

Aufreinigung: Affinity Chromatography.

Immunogen: Peptide from the C-terminal region of Rat mGluR1a.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Andere Bezeichnung: mGluR1a / GRM1a

Hintergrund: The metabotropic Glutamate Receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003).Synonyms: Gprc1a, Metabotropic glutamate receptor 1, Mglur1

Gen-ID: 24414

NCBI Accession: NP_001107802

UniProt: P23385