IFNAR1 Antikörper (pSer535, pSer539)

Produktnummer ABIN372660

Produktdetails anti-IFNAR1 Antikörper

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Bindungsspezifität: pSer535, pSer539

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Non-Human Primate, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFNAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody is specific for the IFNAR1 protein phosphorylated at Ser535,539. Note: The Molecular Weight of the IFNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells, the mature form is ~110-130k.

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Canine, Human, Mouse, Sheep and non-Human Primates.
Species reactivity (tested):Rat.

Aufreinigung: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser535,539 of Human IFNAR1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1000. Immunohistochemistry: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Referenzen für anti-IFNAR1 Antikörper (ABIN372660)

Bhattacharya, HuangFu, Liu, Veeranki, Baker, Koumenis, Diehl, Fuchs: "Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2318-25, (2010) (PubMed).

Details zu IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Andere Bezeichnung: IFNAR1 (IFNAR1 Produkte)

Synonyme: ifnar1 antikoerper, IFNAR1 antikoerper, CD118 antikoerper, Ifar antikoerper, Ifnar antikoerper, Ifrc antikoerper, Infar antikoerper, AVP antikoerper, IFN-alpha-REC antikoerper, IFNAR antikoerper, IFNBR antikoerper, IFRC antikoerper, IFN-R-1 antikoerper, interferon alpha and beta receptor subunit 1 antikoerper, interferon-alpha/beta receptor alpha chain-like antikoerper, interferon (alpha and beta) receptor 1 antikoerper, interferon alpha/beta receptor 1 antikoerper, IFNAR1 antikoerper, ifnar1 antikoerper, Ifnar1 antikoerper, LOC609830 antikoerper

Hintergrund: Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).Synonyms: CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN-R-1, IFN-alpha Receptor alpha, IFN-alpha/beta receptor 1, Interferon-alpha/beta receptor alpha chain, Type I interferon receptor 1

Gen-ID: 3454

NCBI Accession: NP_000620

UniProt: P17181

Pathways: JAK-STAT Signalweg, Hepatitis C