Glutamate Receptor 1 Antikörper (pSer831)

Produktnummer ABIN372652

Produktdetails anti-Glutamate Receptor 1 Antikörper

Target: Glutamate Receptor 1 (GLUR1)

Bindungsspezifität: pSer831

Reaktivität: Human, Ratte, Maus, Hund, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutamate Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Specific for the ~100k GluR1 protein phosphorylated at Ser831. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is completely eliminated by lambda-phosphatase treatment.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Canine, Chicken and Mouse.
Species reactivity (tested):Rat.

Aufreinigung: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser831 of GluR1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Referenzen für anti-Glutamate Receptor 1 Antikörper (ABIN372652)

Barcomb, Coultrap, Bayer: "Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B." in: Molecular pharmacology, Vol. 84, Issue 6, pp. 834-43, (2013) (PubMed).

Jiao, Jalan-Sakrikar, Robison, Baucum, Bass, Colbran: "Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24806-18, (2011) (PubMed).

Sears, Liu, Narayanan, Sharf, Yeckel, Laubach, Aghajanian, DiLeone: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).

Coultrap, Buard, Kulbe, DellAcqua, Bayer: "CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17930-7, (2010) (PubMed).

Davies, Goebel-Goody, Coultrap, Browning: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).

Details zu Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Andere Bezeichnung: Glutamate Receptor 1 / GLUR1 (GLUR1 Produkte)

Synonyme: GLUH1 antikoerper, GLUR1 antikoerper, GLURA antikoerper, GluA1 antikoerper, HBGR1 antikoerper, gluR-A antikoerper, 2900051M01Rik antikoerper, Glr-1 antikoerper, Glr1 antikoerper, GluR-A antikoerper, GluRA antikoerper, Glur-1 antikoerper, Glur1 antikoerper, HIPA1 antikoerper, gluR-K1 antikoerper, GRIA1 antikoerper, glur1 antikoerper, Gria1 antikoerper, glur1b antikoerper, gria1.2 antikoerper, sb:eu293 antikoerper, ZfGluR1a antikoerper, glur1a antikoerper, gria1.1 antikoerper, zfGRIA1[a] antikoerper, glutamate ionotropic receptor AMPA type subunit 1 antikoerper, glutamate receptor, ionotropic, AMPA1 (alpha 1) antikoerper, glutamate receptor, ionotropic, AMPA 1 antikoerper, glutamate receptor, ionotropic, AMPA 1 L homeolog antikoerper, GluR1 protein antikoerper, Glutamate receptor 1 antikoerper, glutamate receptor, ionotropic, AMPA 1b antikoerper, glutamate receptor, ionotropic, AMPA 1a antikoerper, GRIA1 antikoerper, Gria1 antikoerper, gria1 antikoerper, gria1.L antikoerper, glur1 antikoerper, glr-1 antikoerper, gria1b antikoerper, gria1a antikoerper

Hintergrund: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II (McGlade-McCulloh et al., 1993, Mammen et al., 1999, Roche et al., 1996). In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory (Soderling and Derkach, 2000).Synonyms: AMPA-selective glutamate receptor 1, AMPA1, GLUH1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic

Gen-ID: 50592

NCBI Accession: NP_113796

UniProt: P19490

Pathways: PI3K-Akt Signalweg