GABBR2 Antikörper (pSer783)

Produktnummer ABIN372643

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GABBR2 in WB und IF. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Rind (Kuh), Hund, Huhn und Non-Human Primate.

Kurzübersicht für GABBR2 Antikörper (pSer783) (ABIN372643)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Huhn, Non-Human Primate

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABBR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-GABBR2 Antikörper

Bindungsspezifität: pSer783

Spezifität: Specific for ~102k GABAB R2 phosphorylated at Ser783. Immunolabeling of the GABAB R2 band is completely blocked by lambda-phosphatase treatment.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Bovine, Chicken, Mouse, Xenopus and non-Human Primates.
Species reactivity (tested):Rat.

Aufreinigung: Sequential Chromatography on phospho- and dephospho-peptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser783 of GABAB R2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/1000. Immunofluorescence: 1/500 (See Ref.1)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Andere Bezeichnung: GABBR2

Hintergrund: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007).Synonyms: G-protein coupled receptor 51, GABA-B receptor 2, GABA-B-R2, GABBR-2, GPR51, GPRC3B, Gamma-aminobutyric acid type B receptor subunit 2, Gb2, HG20

Gen-ID: 83633

NCBI Accession: NP_113990

UniProt: O88871

Pathways: cAMP Metabolic Process