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GABBR2 Antikörper (pSer783)

GABBR2 Reaktivität: Ratte WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN361471
  • Target Alle GABBR2 Antikörper anzeigen
    GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))
    Bindungsspezifität
    • 18
    • 15
    • 15
    • 15
    • 14
    • 13
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer783
    Reaktivität
    • 90
    • 64
    • 59
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 104
    • 17
    Kaninchen
    Klonalität
    • 96
    • 25
    Polyklonal
    Konjugat
    • 34
    • 10
    • 9
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GABBR2 Antikörper ist unkonjugiert
    Applikation
    • 113
    • 52
    • 52
    • 38
    • 33
    • 16
    • 15
    • 15
    • 13
    • 6
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Spezifität
    Specific for ~102k GABAB R2 phosphorylated at Ser783. Immunolabeling of the GABAB R2 band is completely blocked by (-phosphatase treatment.
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Homologie
    bovine, canine, chicken, human, non-human primates, Xenopus
    Aufreinigung
    Antigen Affinity Purified from Pooled Serum
    Immunogen
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 conjugated to KLH
    Top Product
    Discover our top product GABBR2 Primärantikörper
  • Applikationshinweise
    Recommended Dilution: WB: 1:1000 IF: 1:500 (Kuramoto et al., 2007) Quality Control: Western blots performed on each lot.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Lagerung
    -20 °C
  • Marron Fernandez de Velasco, Hearing, Xia, Victoria, Luján, Wickman: "Sex differences in GABABR-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex." in: Neuropharmacology, Vol. 95, pp. 353-60, (2015) (PubMed).

  • Target
    GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))
    Andere Bezeichnung
    GABBR2 (GABBR2 Produkte)
    Synonyme
    Gpr51 antikoerper, GABABR2 antikoerper, GPR51 antikoerper, GPRC3B antikoerper, HG20 antikoerper, HRIHFB2099 antikoerper, Gb2 antikoerper, Gm425 antikoerper, GABA(B)R2 antikoerper, si:dkey-190l1.2 antikoerper, gamma-aminobutyric acid type B receptor subunit 2 antikoerper, gamma-aminobutyric acid (GABA) B receptor, 2 antikoerper, gamma-aminobutyric acid (GABA) B receptor, 2 S homeolog antikoerper, GABBR2 antikoerper, LOC100448699 antikoerper, gabbr2 antikoerper, Gabbr2 antikoerper, gabbr2.S antikoerper
    Hintergrund
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007). Anti-Phospho-Ser783 GABAB R2 Western blot of rat synaptic membrane showing specific immunolabeling of the ~102 k GABAB R2 protein phosphorylated at Ser783 (control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the phospho-Ser783 GABAB antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.
    Molekulargewicht
    '102 kDa
    Gen-ID
    83633
    UniProt
    O88871
    Pathways
    cAMP Metabolic Process
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