FOXO3 Antikörper (AA 600-673)

Produktnummer ABIN372285

Dieses Anti-FOXO3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FOXO3 in WB und IHC (p). Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Huhn, Affe und Xenopus laevis.

Kurzübersicht für FOXO3 Antikörper (AA 600-673) (ABIN372285)

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Huhn, Affe, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FOXO3 Antikörper

Bindungsspezifität: AA 600-673

Spezifität: This antibody recognizes Forkhead Box O3 (FOXO3)

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Chicken, Dog (Canine), Xenopus, Monkey, Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide corresponding to a portion of the amino acids 600-673 of human FOXO3A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western Blot: 2-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % Sodium Azide as preservative and 0.05 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu FOXO3

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Andere Bezeichnung: FOXO3 / FKHRL1

Hintergrund: FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation. FOXO3A is a transcriptional activator which triggers apoptosis in the absence of survival factors. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO3a has been shown to induce cell growth arrest to effect tumor suppression and FOXO3A genotype is strongly associated with human longevity.Synonyms: AF6q21 protein, FOXO3A, Forkhead box protein O3, Forkhead in rhabdomyosarcoma-like 1

Molekulargewicht: 71 kDa.

Gen-ID: 2309

NCBI Accession: NP_001446

UniProt: O43524

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis