TOLLIP Antikörper

Produktnummer ABIN371662

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TOLLIP in WB, EIA und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TOLLIP Antikörper (ABIN371662)

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TOLLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)

Klon: SB40a

Produktdetails anti-TOLLIP Antikörper

Spezifität: This antibody is specific to Human Tollip. Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins.

Produktmerkmale: Synonyms: Toll-interacting protein

Aufreinigung: Purified

Immunogen: Recombinant Tollip.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot. Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Andere Bezeichnung: TOLLIP

Hintergrund: Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP.Synonyms: Toll-interacting protein

Gen-ID: 54472

UniProt: Q9H0E2