PTK2B Antikörper (AA 400-404)
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- Target Alle PTK2B Antikörper anzeigen
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
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Bindungsspezifität
- AA 400-404
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PTK2B Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Spezifität
- The antibody detects endogenous level of total Pyk2 protein.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
- Immunogen
- Peptide sequence around AA 400-404 (D-I-Y-A-E) derived from Human Pyk2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Isotyp
- IgG
- Top Product
- Discover our top product PTK2B Primärantikörper
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- Applikationshinweise
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2." in: Cancer letters, Vol. 329, Issue 2, pp. 164-73, (2013) (PubMed).
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Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2." in: Cancer letters, Vol. 329, Issue 2, pp. 164-73, (2013) (PubMed).
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- Target
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
- Andere Bezeichnung
- Pyk2 (PTK2B Produkte)
- Synonyme
- CADTK antikoerper, CAKB antikoerper, FADK2 antikoerper, FAK2 antikoerper, PKB antikoerper, PTK antikoerper, PYK2 antikoerper, RAFTK antikoerper, CAKbeta antikoerper, E430023O05Rik antikoerper, Raftk antikoerper, Pyk2 antikoerper, fak1b antikoerper, ptk2.2 antikoerper, ptk2b antikoerper, si:ch1073-355e8.1 antikoerper, protein tyrosine kinase 2 beta antikoerper, PTK2 protein tyrosine kinase 2 beta antikoerper, protein tyrosine kinase 2aa antikoerper, PTK2B antikoerper, Ptk2b antikoerper, ptk2aa antikoerper
- Hintergrund
- Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
- Molekulargewicht
- 140 kDa
- NCBI Accession
- NP_004094
- UniProt
- Q14289
- Pathways
- EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
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