BCL2L1 Antikörper (AA 60-64)
Kurzübersicht für BCL2L1 Antikörper (AA 60-64) (ABIN362598)
Target
Alle BCL2L1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 60-64
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Spezifität
- The antibody detects endogenous level of total BCL-XL protein.
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Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
- Peptide sequence around AA 60-64 (A-D-S-P-A) derived from human BCL-XL . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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Isotyp
- IgG
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Applikationshinweise
- Western blotting: 1:500-1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- BCL2L1 (BCL2-Like 1 (BCL2L1))
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Andere Bezeichnung
- BCL-XL
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Hintergrund
- Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
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Molekulargewicht
- 30 kDa
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NCBI Accession
- NP_612815
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UniProt
- Q07817
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Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
Target
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