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Nibrin Antikörper (AA 341-345)

NBN Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated

Produktnummer ABIN362592

Datenblatt (PDF)

Target Alle Nibrin (NBN) Antikörper anzeigen

Nibrin (NBN)
Bindungsspezifität
36

15

12

8

7

5

5

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 341-345
Reaktivität
98

60

36

2

1

1

1

1
Human
Wirt
115

15
Kaninchen
Passende Sekundärantikörper
Klonalität
106

24
Polyklonal
Konjugat
64

8

6

6

6

6

6

6

5

3

2

2

2

2

2

2

2
Dieser Nibrin Antikörper ist unkonjugiert
Applikation
101

45

27

27

26

25

23

17

9

8

6

4

2

2

1
Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität

The antibody detects endogenous level of total p95/NBS1 protein.

Aufreinigung

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

Peptide sequence around AA 341-345 (S-L-S-Q-G) derived from Human p95, NBS1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotyp

IgG

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Applikationshinweise

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target

Nibrin (NBN)

Andere Bezeichnung

p95/NBS1 (NBN Produkte)

Synonyme

NBN antikoerper, AT-V1 antikoerper, AT-V2 antikoerper, ATV antikoerper, NBS antikoerper, NBS1 antikoerper, P95 antikoerper, Nbs1 antikoerper, im:6911679 antikoerper, zgc:194152 antikoerper, nibrin antikoerper, NBN antikoerper, nbn antikoerper, Nbn antikoerper

Hintergrund

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Molekulargewicht

95 kDa

NCBI Accession

NP_002476

UniProt

O60934

Pathways

DNA Reparatur, Production of Molecular Mediator of Immune Response